Nevada had five 40-plus-yard touchdowns. Daniel Brown returned an interception 42 yards, Mannix scored from 47 and 58 yards out, Jaxson Kincaide added a 73-yard grab and Romeo Doubs went 80 yards on a punt return.
It was the fifth-highest scoring output in Nevada's history and the most in its FBS era, which began in 1992.
Gangi was 16-of-26 passing for 342 yards and three TDs, and Mannix caught four passes for 132 yards. Doubs gave Nevada its first punt return touchdown since 2011.
Nevada scored 23 unanswered points for a 23-9 lead and it was 30-19 at halftime before the Wolf Pack took control with 42 straight points.
Touchdowns on six straight drives put Nevada ahead 58-19.
South Carolina commit Mecose Todd runs through practically the whole defense, breaking every tackle attempted, on his way for a touchdown.
Heather Dinich details four Maryland football players accounts of the death of Jordan McNair included in independent report released Friday.
J.T. Daniels passed for 241 yards and three touchdowns, and Jay Tufele blocked Washington State's attempt at a tying field goal with 1:41 to play in Southern California's 18th consecutive home victory, 39-36 Friday night.
USC DL Jay Tufele blocks Blake Mazza's 38-yard field-goal attempt as USC hangs on to win 39-36.
Miles Sanders puts on the jets against Illinois, running up 200 yard and three touchdowns.
Vavae Malepeai runs up the middle for a 2-yard touchdown.