Gonzalo Martinez got the first from the penalty spot, before Giovani Lo Celso doubled their lead with a sweetly struck half volley from 25 yards.
2016 ScheduleAll times ET
Argentina travel to the United States to take on Guatemala in Los Angeles on Sept. 7 without the Barcelona striker, who is taking a break.
FIFA has lifted its suspension of the Guatemala football federation, clearing the Central American country to vote for the 2026 World Cup hosts.
FIFA has imposed a life ban from football on a Guatemalan official who took bribes linked to marketing deals for World Cup qualifying games.
A former judge who led Guatemala's football federation has become the first person sentenced in the U.S. in the FIFA corruption scandal.
Former Major League Soccer MVP Carlos Ruiz has announced his retirement at age 37.
FIFA has banned the former president of the Guatemala football federation for life.
FC Dallas veteran Carlos "Pescadito" Ruiz has said he will run for president of the Guatemala football federation and fight for transparency.
With his back against the wall, U.S. manager Jurgen Klinsmann resorted to pragmatism, and his charges duly responded by thrashing Guatemala.
Facing a must-win situation in the quest to qualify for the 2018 World Cup, the United States responded with a 4-0 victory over Guatemala on Tuesday.
Watch Live: United States hosts Guatemala in must-win match; loss would seriously endanger qualifying for 2018 World Cup
U.S. Soccer starting XI: Guzan; Yedlin, Cameron, Birnbaum, Castillo; Beckerman, Bradley, Zusi; Zardes, Dempsey, Wood
Jurgen Klinsmann made five changes to the United States' lineup ahead of Tuesday night's must-win World Cup qualifier against Guatemala.
The U.S. men's national team is faced with one of the most nerve-racking matchups of Jurgen Klinsmann's reign as head coach.
Join the Boot Room as the United States host Guatemala in CONCACAF World Cup qualifying.
United States coach Jurgen Klinsmann believes that Tuesday's World Cup qualifying rematch against Guatemala is a must-win.
Combined with disappointing performances in the Gold Cup, the U.S. is regressing. Jurgen Klinsmann needs to find a fix -- and quickly.
Friday's 2-0 World Cup qualifying defeat to Guatemala was arguably the U.S.'s worst under Jurgen Klinsmann, and it makes Tuesday's rematch a must win.
The United States slumped to a disappointing 2-0 defeat against Guatemala in their first 2018 World Cup qualifier of 2016.
Join the Boot Room for CONCACAF World Cup qualifying: Guatemala vs. United States and Canada vs. Mexico.
Guatemala spent years as minnows but are rebuilding nicely under new coach Walter Claveri. The U.S. don't expect an easy win.
Former Guatemala football federation president Brayan Jimenez was due to appear in Brooklyn federal court on Wednesday, according to reports.
Brayan Jimenez, the former president of the Guatemalan Football Federation, has been arrested and faces extradition to the United States.
The United States will play its March 29 World Cup qualifier against Guatemala at Columbus, Ohio.
Jamaica waited until the 89th minute at Nicaragua but finally found the crucial goal for a 2-0 win that kept them alive in World Cup qualifying.