Federico Chiesa celebrated his 100th appearance for Fiorentina by inspiring them to come from two goals down to draw 3-3 at home to Atalanta.
Lazio and AC Milan played to a turgid 0-0 draw in the first leg of their Italian Cup semifinal as both sides failed to create any clear-cut chances.
Lazio reached the Coppa Italia semifinals after a 4-3 shootout win over Inter Milan and will face AC Milan in the last four.
Roma striker Edin Dzeko could be given a lengthy ban if allegations of spitting at the referee during thr 7-1 defeat at Fiorentina are confirmed.
Juventus were eliminated from the Coppa Italia and Barcelona made the Copa del Rey semis. Here are the best numbers from the mid-week matches.
Juventus' hopes of winning the treble have been ended after they were knocked out of the Coppa Italia 3-0 by Atalanta.
Federico Chiesa scored a hat trick as Fiorentina humiliated AS Roma 7-1 to reach the Coppa Italia semifinals on Wednesday.
Krzysztof Piatek scored twice on his first start for AC Milan as they beat Napoli 2-0 to reach the Coppa Italia semi-finals on Tuesday.
Napoli striker Arkadiusz Milik scored one goal and provided an assist for another as his side beat Sassuolo 2-0 in a Coppa Italia round of 16 match.
Antonio Candreva and Lautaro Martinez scored two goals apiece as Inter Milan thumped Benevento 6-2 on Sunday in a Coppa Italia match.
Cristiano Ronaldo was among several regulars who didn't start though defending champion Juventus nevertheless eased into the Coppa quarterfinals.
Patrick Cutrone came off the bench to fire AC Milan into the Coppa Italia quarterfinals on Saturday with both goals in a 2-0 win over Sampdoria.
There were reports of Lazio supporters chanting about Rome's African population and antisemitic abuse aimed at Roma supporters against Novara.