Barcelona took care of Sevilla at the Camp Nou, but victory came at a price as star-man Lionel Messi was subbed off in the 15th minute with an apparent arm injury.
Fabián Ruiz's beautifully-curled opener set the tone for Napoli to secure a see out a 0-3 win away at Udinese.
Mohamed Salah's neat finish in the first-half proved decisive as Liverpool stumbled past a valiant Huddersfield.
Steve Nicol sees Antonio Conte as a good short-term solution for Real Madrid should the club decide to part ways with Julen Lopetegui.
Two goals in 58 first-half seconds saw a dominant Watford seal their first win since September and end Wolves' six-game unbeaten run.
Beram Kayal's first half strike saw Brighton take three points from St James' Park, sending Newcastle to the bottom of the table.