PHILADELPHIA -- Once Aaron Nola got an early lead, he was home free.
Nola (14-3) allowed one run on three hits with one walk while lowering his ERA in 2.24. The All-Star is even better at home, improving to 9-0 with a 2.00 mark in 12 starts in Philadelphia this season.
"There's been a lot of Cy Young Award chatter leading up to today. Obviously, you can see why," Phillies manager Gabe Kapler said.
"He rises to the occasion. he's ready for the biggest moment. And it's just like no spot is too big. No spotlight is too bright. He just elevates his game, and we saw that tonight," he said.
Pat Neshek pitched a scoreless ninth for his third save in as many chances.
Syndergaard (8-3) allowed four runs on eight hits with five strikeouts and two walks in 5 2/3 innings. The tall right-hander has battled injuries again in 2018, missing two months with a finger injury and then 10 days last month due to hand, foot and mouth disease.
"Today was more of a step in the wrong direction," he said.
Austin Jackson had three hits and an RBI for the Mets.
Cabrera's double put the Phillies ahead and Williams followed with an RBI single. Cabrera, traded from the Mets to Philadelphia last month, scored on Carlos Santana's double-play groundout.
That was more than enough for Nola, who struck out the side in the first and retired nine of the first 10 Mets. The only batter that reached during that stretch, Jose Bautista, got on because of an error by second baseman Cesar Hernandez.
"Just trying to make quality pitches," Nola said.
The Phillies stole a season-high five bases, including the first two of the season by the catcher Alfaro, against Syndergaard.
"Definitely an Achilles' heel," Syndergaard said of holding runners. "Embarrassing tonight."
Mets manager Mickey Callaway said it's an area Syndergaard will continue to work to improve.
"Bottom line is he needs to get better and I think he will," Callaway said.
Hernandez's misplay made it 94 errors for Philadelphia, which began play second in the majors to St. Louis (95).
Mets: An MRI on the left index finger of RF Brandon Nimmo revealed no structural damage. Nimmo, who was injured on Thursday, was not in the lineup Friday but could play on Saturday. ... Reliever Bobby Wahl was placed on the DL with a right hamstring strain and LHP Daniel Zamora was recalled from Double-A Binghamton. Zamora made his major league debut, pitching 1 1/3 scoreless innings with two strikeouts.
Mets ace Jacob deGrom (7-7, major league-best 1.81 ERA) opposes RHP Jake Arrieta (9-7, 3.33) in the fourth game of the five-game set on Saturday afternoon. DeGrom is 6-1 with a 2.45 ERA in 13 career starts against the Phillies and struck out seven in eight shutout innings of a 3-0 win on July 11. Arrieta is 2-2 with a 1.99 ERA in eight career starts vs. the Mets.
Kolten Wong hit the first of four St. Louis homers, Miles Mikolas won his third straight start and the Cardinals beat the NL East-leading Atlanta Braves 11-6 on Monday night to give their playoff push another boost.
Yadier Molina's 2-run homer in the top of the 9th inning puts the Cardinals up 11-6 over the Braves.
Rookie pinch-hitter Daniel Vogelbach's first career grand slam with two outs in the eighth inning lifted the Seattle Mariners over the Houston Astros 4-1 on Monday night.
Harrison Bader sends a high-flying ball over the wall as three runs score to break the game open against the Braves.
Kolten Wong smashes a solo home run to right field in the top of the fourth inning as a part of his 3-RBI night.
Paul DeJong drives a 2-run homer to left-center field in the 5th inning of the Cardinals' route of the Braves.