The former closer did it on a day when the Giants celebrated their 2010 World Series championship, a team that had more than its fair share of tight finishes.
Melancon got pinch-hitter Carlos Perez to fly out with the bases loaded in the ninth inning, preserving a 5-3 win over Texas Rangers on Saturday.
"It's really incredible how similar the two games were but we found a way to get the last out today," San Francisco manager Bruce Bochy said. "Torture was back."
San Francisco began the day nine games behind Milwaukee for the second NL wild card.
"It's very important to continue to send that message of relentless attack," Pence said. "Even where we are and as clouded as it may seem, you still never know. When there's still a chance in this game of baseball, things can get hot in an instant."
Hours after Bochy confirmed that six-time All-Star catcher Buster Posey is headed for season-ending hip surgery, San Francisco did the bulk of its scoring in the first inning then held on behind Suarez and three relievers for a rare win at AT&T Park.
Suarez (5-9) struck out five and walked three to win for the first time since July 29. The left-hander induced 12 groundouts and two double plays.
"This whole week I looked at old video just to see what could get me going again," Suarez said. "Once I know I'm getting a lot of groundballs I know that's when I'm in my game."
The Giants have the fourth-best winning percentage in the NL at home but had lost 10 of the previous 13 at their waterfront ballpark before edging the Rangers.
Rougned Odor homered and had three hits for Texas.
"The difference is we didn't get the big hit when we needed to there late," Rangers manager Jeff Banister said. "We felt good about our situation once we got some baserunners there in the last inning. We were unable to come up with the big hit."
Crawford homered off Martin Perez (2-6) in the first, a three-run blast to center. The Giants shortstop entered the day batting .178 since July 1, the lowest average in the majors among players with at least 150 plate appearances.
Pence had a pinch-hit home run off Matt Moore in the seventh.
Odor, who hit a tying two-run home run in the ninth Friday, trimmed the lead to 5-3 with a three-run shot off Hunter Strickland in the eighth. Two batters earlier, a two-out fielding error by left fielder Austin Slater extended the inning.
IN A RUT
Perez allowed four runs in the first inning then yielded only two hits over the next four innings. The lefty, who missed more than two months on the DL because of pain in his right elbow, is winless since April 22.
"The first inning I threw just one bad pitch," Perez said. "After that I shut it down and just tried to get zeroes."
Rangers: IF Hanser Alberto was placed on the disabled list with a right hamstring strain, an injury he suffered Friday in his first game after being called up to take Bartolo Colon's roster spot. Carlos Perez was called up from Triple-A Round Rock. RHP Nick Gardewine was placed on the 60-day DL with a right forearm strain.
Giants: Posey will undergo hip surgery Monday in Colorado and will miss 6-8 months, ending what has been a painful and frustrating year for the six-time All-Star. RHP Jeff Samardzija will seek a second opinion on his troublesome pitching shoulder. Samardzija has been on the DL since July 15.
Rangers RHP Yovani Gallardo (7-2, 6.06 ERA) has six wins in 10 career starts against the Giants. San Francisco LHP Derek Holland (6-8, 3.75), who won 62 games over eight seasons with Texas, makes his third career appearance against his former club.
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Right-hander Mike Fiers will look to continue his strong pitching at home while attempting to extend his dominance of the Minnesota Twins when he takes the mound for the Oakland Athletics on the middle day of a three-game series Saturday night.
While the long ball is getting all the attention for the Los Angeles Dodgers of late, they have also used an old reliable to get them in position to grab their sixth consecutive National League West title.
This spring, Colorado Rockies manager Bud Black told his players they are good enough to win anywhere.
Hunter Renfroe hit a two-run homer, Freddy Galvis added a solo shot and the last-place San Diego Padres beat the Los Angeles Dodgers 5-3 on Friday night.
Khris Davis hit his second homer of the night leading off the bottom of the 10th inning for career-high No. 45, sending the Oakland Athletics past the Minnesota Twins 7-6 on Friday night.
The New York Yankees are inching closer toward clinching a wild-card spot for the second straight season. They also want to be the home team for the one-game playoff while giving certain players some rest.