1 p.m. ET | CBS
Matchup rating: 51.3 | Spread: BUF -6.5 (39.5)
What to watch for: This is Stefon Diggs' and Josh Allen's first game together, and it comes against a mediocre Jets secondary. Look for the third-year quarterback to target the Bills' new star receiver often as they continue to build chemistry with one another. -- Marcel Louis-Jacques
Bold prediction: The Jets will score only one touchdown, and it won't happen until late in the game. In his last six games against Sean McDermott-coached defenses, Adam Gase's offenses haven't scored more than 21 points -- and the average per game is just 16.5. The Jets' offense has so many new pieces that it's hard to imagine an efficient performance. -- Rich Cimini
Stat to know: Jets quarterback Sam Darnold went 6-2 over the final eight games of the 2019 season, throwing 13 touchdowns and four interceptions. His first five? A 1-4 record, six TDs and nine interceptions.
What to know for fantasy: The Bills' Allen has just one touchdown pass in his career against the Jets (78 passes thrown), but he has scored 25.9 fantasy points with his legs in his two full games against the divisional rival. See Week 1 rankings.
Betting nugget: The underdog has won four of the last five meetings outright in this series. Read more.
Cimini's pick: Bills 24, Jets 13
Louis-Jacques' pick: Bills 31, Jets 10
FPI prediction: BUF, 62.9% (by an average of 4.8 points)
Matchup must-reads: Jets' Gore begins 16th NFL season with Gore Tour ... Bills GM: Not 'on track' until we win AFC East ... Jets GM says team angered by low expectations ... Bills' White gets extension, to be highest-paid CB ... Jets 2020 season preview: Enough playmakers around Darnold? ... Bills 2020 season preview: Can Allen lead them to a title?