1 p.m. ET | CBS
Matchup rating: 32.5 | Spread: CHI -5.5 (42)
What to watch for: The focus is squarely on Bears quarterback Mitchell Trubisky. The embattled former second-overall pick led Chicago to a memorable fourth-quarter comeback in Week 1, but not even Trubisky's three touchdown passes in the final 15 minutes could cover up for how inconsistent he played in the opening three quarters at Ford Field. Head coach Matt Nagy wants even play from the 25-year-old quarterback. The Giants might present Trubisky with an opportunity to have a more balanced performance on Sunday. -- Jeff Dickerson
Bold prediction: Bears wide receiver Allen Robinson II tops 150 yards receiving. Clearly, Robinson is not happy with his contract, and what better way to prove he deserves to get paid than to play against the Giants defense? Robinson's best game last year came against the Giants, when he had 131 yards receiving and a touchdown. The Bears put him in the slot throughout that game and let him eat. The Giants apparently haven't fixed that problem. JuJu Smith-Schuster caught six passes on six targets for 69 yards and two touchdowns out of the slot against this Giants defense on Monday night. -- Jordan Raanan
Stat to know: Giants running back Saquon Barkley has just six rushing yards in Week 1 and averaged minus-0.2 yards before contact per rush. His 3.96 yards per rush since Week 7 of last season is the 10th-lowest in the NFL among 32 players with at least 100 rushes in that span.
Betting nugget: Chicago is 1-6 ATS in its last seven games as a favorite. Read more.
Raanan's pick: Bears 22, Giants 21
Dickerson's pick: Bears 21, Giants 18
FPI prediction: CHI, 65.5% (by an average of 5.7 points)
Matchup must-reads: Can Giants' Slayton continue to produce like a No. 1 receiver? ... Trubisky leads Bears to comeback