4:05 p.m. ET | Fox
Matchup rating: 57.2 | Spread: NO -5.5 (43.5)
What to watch for: With his injury-ravaged defense, how will Broncos coach Vic Fangio keep Saints quarterback Taysom Hill in the pocket and make him at least a little uncomfortable when he is going through his progressions? Fangio has made life somewhat difficult for young quarterbacks in the first time they face his defense, and while Hill is no rookie as a player, he still has just 41 career pass attempts, with 23 of those coming last week. -- Jeff Legwold
Bold prediction: Hill and running back Alvin Kamara will each throw their first career TD passes. Why not? The Saints used Kamara in some Wildcat formations last week while getting creative during QB Drew Brees' absence, and he is 1-for-1 in his career throwing the ball. Hill, meanwhile, had two rushing touchdowns but no passing TDs in his first career start at quarterback last week. -- Mike Triplett
Stat to know: The Saints are one of four teams with five or more games of 15-plus quarterback pressures (Buccaneers, Chiefs and Rams). They had 18 last week against the Falcons.
What to know for fantasy: Kamara only has one game this season with 15-plus carries, making the first zero-catch performance of his NFL career last week with Hill under center that much more concerning in terms of sustaining fantasy excellence. Kamara was a top-10 RB in each of his first nine games this season. See Week 12 rankings.
Betting nugget: Since the start of last season, New Orleans is 6-0 ATS and straight up without Brees -- Teddy Bridgewater and Hill were the fill-ins -- despite being an underdog in four of the six games. Read more.
Triplett's pick: Saints 26, Broncos 20
Legwold's pick: Saints 23, Broncos 21
FPI prediction: NO, 69% (by an average of 6.6 points)