1 p.m. ET | FOX
Matchup rating: 51.4 | Spread: NO -4.5 (54)
What to watch for: So much attention will be paid to whether or not Michael Thomas plays, and if so, how effective he'll be. But take a look at one of the players on the Lions, as well. In six career games against the Saints, Matthew Stafford has averaged 303.2 yards per game. And dating back to 2009, five of the seven matchups between these teams have seen the winner score 30-plus points. So figure a high-scoring game is coming once again. -- Michael Rothstein
Bold prediction: The Saints' stars will break out of their rut. Thomas will return from his ankle injury and catch his first touchdown pass of the season from Drew Brees, while defensive end Cameron Jordan will get his first two sacks of the year. -- Mike Triplett
Stat to know: The Saints have been called for nine defensive pass interference penalties, which is already tied with 2017 Bengals for the most DPI penalties through four games over last 20 seasons, despite not yet playing their fourth game.
Betting nugget: The Saints are an NFL-best 24-9 ATS on the road since the start of the 2016 season. They're 12-4 ATS as road favorites in that time. Read more.
Triplett's pick: Saints 30, Lions 22
Rothstein's pick: Saints 38, Lions 31
FPI prediction: NO, 66.0% (by an average of 5.7 points)
Matchup must-reads: Saints' defense deserves its own scrutiny for 1-2 start ... Defense offers Lions a brief glimmer of hope ... Time to worry about Brees and the Saints? ... Making sense of Walker's usage ... Payton: Two straight losses 'bit of a gut check' for undisciplined Saints