1 p.m. ET | FOX
Matchup rating: 49.6 | Spread: GB -6 (48.5)
What to watch for: Can Packers receiver Davante Adams have another big day after his career-high 14-catch performance in Week 1 against the Vikings? Well, the Lions secondary is banged up, and Adams is a tough cover. He had at least one catch on nine different route types last week, according to ESPN Stats & Information using NFL Next Gen Stats. The Lions played man coverage on 82% of their defense snaps in Week 1, the highest rate of any team on opening weekend. -- Rob Demovsky
Bold prediction: Green Bay quarterback Aaron Rodgers throws four more touchdowns this week against Detroit. Rodgers has had just intermittent success against Matt Patricia's Lions, but this is a different Detroit secondary. Its corners are banged up -- Desmond Trufant and Darryl Roberts both missed practices this week -- and rookie Jeff Okudah might be making his debut. Depending how the Lions match up, that debut could come against Adams. So watch for Rodgers to slice through a depleted Lions secondary. -- Michael Rothstein
Stat to know: Per the Elias Sports Bureau, only two teams have gone 2-0 against an opponent in a season without ever holding a lead in regulation. The first was the 1977 49ers, who bested the Saints twice. The second was the 2019 Packers, who won both of their games against Detroit last season on game-ending field goals despite not holding a lead at any point in either game.
What to know for fantasy: Adams was the top scoring player in Week 1 (41.6 points) and has caught six touchdown passes over his past six matchups with the Lions. See Week 2 rankings.
Betting nugget: The Lions have covered in six straight games against the Packers. Read more.
Rothstein's pick: Packers 35, Lions 23
Demovsky's pick: Packers 31, Lions 25
FPI prediction: GB, 68.0% (by an average of 6.7 points)
Matchup must-reads: Why Patricia's team struggles to close out games ... No tailgating: Lambeau closed to fans ... Once deep at CB, Lions now thin after injuries facing Rodgers ... Rodgers-Adams combo rivaling Nelson-Rodgers