4:25 p.m. ET | Fox
Matchup rating: 72.7 | Spread: IND -2.5 (51)
What to watch for: Buckle up for the Colts' No. 1 defense and the Packers' No. 6 offense. Colts coach Frank Reich said Green Bay will be the toughest test of the season so far for his defense, but the Colts will also be the second top-three defense the Packers have faced this season. Tampa Bay, which is No. 3 in the NFL in total defense, held Green Bay to 201 total yards, sacked Aaron Rodgers five times, forced two turnovers and gave up only 10 points to the Packers earlier this season. -- Mike Wells
Bold prediction: Indianapolis QB Philip Rivers will outplay Green Bay's Rodgers. Rivers was efficient against the Packers' defense last season, and the Colts' elite defense will give Rodgers fits just like the Bucs' D did in Tampa earlier this season. -- Rob Demovsky
Stat to know: Rodgers leads the NFL with an 84.8 Total QBR this season and has three games with 300-plus passing yards and four-plus passing TDs (tied with Patrick Mahomes for the most such games). Oh, and he is 4-0 and is averaging 296.5 pass yards per game with nine passing scores in his past four games played at indoor stadiums, dating back to last season.
What to know for fantasy: You might have missed Marquez Valdes-Scantling's big Week 10, but be careful. Yes, the Packers wide receiver has three games with more than 19 fantasy points this season, but he also has three games with fewer than 3.5 and is facing the seventh-best defense against fantasy WRs. See Week 11 rankings.
Betting nugget: Under coach Matt LaFleur, Green Bay is 5-1 outright and ATS as a road underdog (regular season). Read more.
Demovsky's pick: Colts 27, Packers 23
Wells' pick: Colts 30, Packers 24
FPI prediction: GB, 54.1% (by an average of 1.4 points)
Matchup must-reads: Next or never? What Bakhtiari's deal with Packers means for Jones ... Schedule favors Colts, not Titans, for playoff spot in loaded AFC ... Packers activate Lazard, return offense to full strength ... Colts LB Leonard motivated by Rodgers slight ... A new Packers' Valdes-Scantling or same old MVS?: Only time will tell