4:05 p.m. ET | CBS
Matchup rating: 30.8 | Spread: LAC -7 (44)
What to watch for: Will Chargers quarterback Justin Herbert be even better after working all week with the starters? He drew praise from his coaches after stepping into the starting lineup in Week 2 just minutes before kickoff. Now they've had a week to work with him. Coach Anthony Lynn says he's as shy on the field as off it, but he looked sharp in his debut for the most part. -- Shelley Smith
Bold prediction: The Panthers will get a sack and two QB pressures. Not bold? Consider that the Panthers still have no sacks through two games and only six pressures. But with the tendency of rookie quarterbacks to hold onto the ball too long trying to make a play, this feels like the game the sack-less streak ends. -- David Newton
Stat to know: The Chargers have called a designed rush on 54% of their offensive plays this season, the second-highest rate in the NFL behind only the Rams (55%), after being ranked 25th in the NFL in designed rush percentage last season (36%).
Betting nugget: The over is 11-4 in Carolina's past 15 games. Read more.
Newton's pick: Chargers 23, Panthers 17
Smith's pick: Chargers 24, Panthers 17
FPI prediction: LAC, 63.4% (by an average of 4.8 points)
Matchup must-reads: McCaffrey injury gives Panthers' Bridgewater an opportunity ... Chargers QB Taylor's lung punctured by team doctor before Chiefs game ... Panthers believe in Davis with McCaffrey injured ... McCaffrey out 4-6 weeks with high ankle sprain