1 p.m. ET | CBS
Matchup rating: 50.6 | Spread: TEN -2.5 (48)
What to watch for: Will the Vikings offense be able to keep up with Tennessee's scoring pace? Minnesota's defense has struggled to get its opponents off the field, and the lack of opportunities for its offensive playmakers not named Adam Thielen has been noticeable. Is this the week when the offense leans heavily on running back Dalvin Cook, and can quarterback Kirk Cousins finally involve rookie receiver Justin Jefferson and/or tight end Irv Smith Jr.? -- Courtney Cronin
Bold prediction: Titans QB Ryan Tannehill will finish with 300-plus passing yards. That may not seem bold, but here's something to consider: Tannehill has finished with 300 or more passing yards only three times since taking over in Week 7 last season. Defenses are focused on stopping Derrick Henry, which presents one-on-one matchups for the receivers. Tannehill and the passing game should have the advantage against a depleted Vikings secondary in those situations. -- Turron Davenport
Stat to know: The Titans are seeking their first 3-0 start since 2008 (started 10-0 and finished 13-3), while the Vikings are trying to avoid their first 0-3 start since 2013 (the last Vikings team to lose 10-plus games).
What to know for fantasy: Since 2018, Henry is averaging 54.4% more points per game when his team is favored than when it is the underdog. See Week 3 rankings.
Betting nugget: Minnesota is 7-3 ATS as a home underdog under Mike Zimmer, including the playoffs. Read more.
Davenport's pick: Titans 28, Vikings 14
Cronin's pick: Titans 31, Vikings 20
FPI prediction: MIN, 51.5% (by an average of 0.6 points)