1 p.m. ET | Fox
Matchup rating: 61.1 | Spread: ARI -2.5 (49.5)
What to watch for: The Cardinals lead the NFL in accepted penalties (79), while the Patriots have the fewest in the league (36). But the Patriots are coming off a rare seven-penalty game in a loss to Houston, which could be a sign that things are headed in the wrong direction for them. How much does the penalty discrepancy show up on Sunday? -- Mike Reiss
Bold prediction: Cardinals quarterback Kyler Murray will make up for his injured right shoulder with his feet. He'll run for 125 yards -- a career high -- as the defensive-minded Bill Belichick will be forced to pull out all the stops while trying to slow the young phenom. -- Josh Weinfuss
Stat to know: Arizona's DeAndre Hopkins leads the NFL with 912 receiving yards. He is seeking to become just the fifth Cardinals player in the Super Bowl era with at least 1,000 receiving yards through 11 team games and the first since Larry Fitzgerald did it in 2008.
What to know for fantasy: Feeling lucky? Cardinals receiver Christian Kirk has as many 20-point fantasy games this season as he does games with eight or fewer fantasy points (three). See Week 12 rankings.
Betting nugget: Arizona is 5-2 against the spread (ATS) in games starting at 1 p.m. ET in the Kliff Kingsbury/Kyler Murray era. Read more.
Weinfuss' pick: Cardinals 34, Patriots 17
Reiss' pick: Patriots 27, Cardinals 24
FPI prediction: ARI, 51.8% (by an average of 0.7 points)
Matchup must-reads: Among Kingsbury's New England lessons: He was not the next Brady ... After struggling vs. Watson, Pats' defense gets Murray next ... Cardinals add WR Larry Fitzgerald to reserve/COVID-19 list.