1 p.m. ET | Fox
Matchup rating: 9.0 | Spread: NYG -3 (43)
What to watch for: We get Washington defensive end Chase Young up against Giants left tackle Andrew Thomas -- the No. 2 overall pick from April matched against the struggling No. 4 overall selection. It's been a rough start for Thomas, as he's ranked 61st out of 68 tackles in pass-block win rate (79.4%), an ESPN metric powered by NFL Next Gen Stats. Young, meanwhile, flashed his form early before missing some time with a groin injury. He returned last weekend and should be close to 100 percent and a handful for Thomas off the edge. -- Jordan Raanan
Bold prediction: Washington defensive end Montez Sweat will take advantage of a weak New York offensive line and beat right tackle Cameron Fleming for a sack/fumble that leads to a deciding touchdown for Washington. Furthermore, Washington will record four sacks to break a three-game skid against the Giants. It ranks fifth in sacks with 15, but eight occurred in the opener. Against this line, Washington's pass rush will get healthy. -- John Keim
Stat to know: The Giants are last in the NFL in rushing, with just 79.0 yards per game. But Washington is second to last at 81.4 rushing yards per game.
What to know for fantasy: In Weeks 2-4, Giants wide receiver Darius Slayton totaled 134 yards on nine catches. In Week 5, he racked up 129 yards on eight catches against a divisional foe in the Cowboys. In Week 6, he gets another NFC East rival that has been routinely challenged deep down the field by opponents. See Week 6 rankings.
Betting nugget: In the past 35 seasons, when a team with an 0-5 or worse record is favored, the under is 12-6. Read more.
Keim's pick: Washington 21, Giants 20
Raanan's pick: Giants 23, Washington 22
FPI prediction: WSH, 52.7% (by an average of 1 point)
Matchup must-reads: Resetting Washington's QB situation: What's next for Allen, Smith and Haskins ... Giants' Jones continues to be haunted by last-minute failures ... Smith favored to win comeback player award ... Giants lose LB Carter for season with ruptured Achilles