1 p.m. ET | CBS
Matchup rating: 53.6 | Spread: PIT -7.5 (41.5)
What to watch for: The Steelers shut down one of the league's premier running backs Monday night, only allowing Saquon Barkley 6 rushing yards. The Broncos' rushers fared a bit better against the Titans, averaging 4.1 yards per carry, but they enter Sunday's matchup with a question mark on Phillip Lindsay's availability. Look for the Steelers' defense to dominate yet another ground game. -- Brooke Pryor
Bold prediction: The Broncos will sack Ben Roethlisberger at least four times and force at least once turnover on a QB hit. Yes, Von Miller is out for the year, Bradley Chubb is still working his way back from last season's ACL surgery and the Broncos were tepid in the pass-rush in much of their Week 1 loss to the Titans. But Roethlisberger has faced the Broncos nine times in his long career, and the Broncos have sacked him at least three times in seven of those games -- and at least four in four of them. -- Jeff Legwold
Stat to know: The Steelers have gone 58 straight games with at least one sack, tied for the sixth-longest streak by any team since 1970. A sack in this one would tie them for the fifth-longest streak.
What to know for fantasy: Roethlisberger (22.1 points) was better in Week 1 than the healthy version of him we saw in 2018 (21.4 points per game), as he threw three touchdown passes on just 32 attempts (zero TD passes on 62 attempts before his season ended in 2019). See Week 2 rankings.
Betting nugget: The Broncos have failed to cover their last four games off less than a full week of rest. Read more.
Legwold's pick: Steelers 20, Broncos 17
Pryor's pick: Steelers 31, Broncos 16
FPI prediction: PIT, 66.8% (by an average of 6.2 points)
Matchup must-reads: QB Lock shows his leadership in season-opening loss ... Steelers' Roethlisberger is sore, but elbow is good after first game ... After drops, Broncos' Jeudy determined to prove 'failure is growth'