8:20 p.m. ET | NBC
Matchup rating: 81.8 | Spread: LAR -3.5 (51.5)
What to watch for: The 49ers' struggling offensive line gets its toughest test yet with Aaron Donald & Co. coming to town. The Rams are tied for the NFL lead with 20 sacks, and the Niners have allowed 18, fourth most in the league. Donald is capable of wrecking games by himself, and the Niners' interior line has been of particular concern. If San Francisco can't get it figured out in a hurry, it could be another long night. -- Nick Wagoner
Bold prediction: Donald will turn in his third multi-sack performance of the season. The defensive tackle is coming off a four-sack performance and will continue to wreak havoc in the backfield against the 49ers, whom he has 11.5 career sacks against. -- Lindsey Thiry
Stat to know: Rams quarterback Jared Goff has a 70% completion rate in three consecutive road games, the second-longest streak in Rams history (Kurt Warner, five).
What to know for fantasy: Los Angeles running back Darrell Henderson has three games with at least 14 touches this season. He has rushed for a score in all three of those games, and he even caught a touchdown last weekend at Washington. See Week 6 rankings.
Betting nugget: San Francisco is 0-3 ATS and straight up at home this season. The Niners' only two wins have come at MetLife Stadium (defeating the Giants and Jets). Read more.
Thiry's pick: Rams 28, 49ers 24
Wagoner's pick: Rams 30, 49ers 27
FPI prediction: LAR, 53.0% (by an average of 1.1 points)
Matchup must-reads: Rams' Sean McVay remains a football junkie even as he attempts to step back ... How Kyle Shanahan has kept the 49ers from falling apart ... Rams have a sack party in Washington as they prepare for NFC West ... 49ers CB Sherman suffers setback in recovery from calf injury ... 49ers QB Garoppolo practices, on track to start