8:20 p.m. ET | NBC
Matchup rating: 83.6 | Spread: TB -5.5 (51.5)
What to watch for: Wide receiver Antonio Brown will make his debut with the Buccaneers, who look to avenge a Week 1 loss at New Orleans and maintain hold of the NFC South. Buccaneers coach Bruce Arians said they're "light years" from where they were in Week 1 as an offense, and Todd Bowles' defense has become one of the league's best. But that D has shown some vulnerability over the past two weeks against the Raiders and Giants, having to overcome slow starts and rely on second-half interceptions to be the difference-makers. It'll need a much faster start against Drew Brees. -- Jenna Laine
Bold prediction: Bucs quarterback Tom Brady will burn the Saints with a 50-yard TD pass. OK, this one actually isn't so bold, since the Saints have allowed an astounding seven passes of 48-plus yards over their past five games. New Orleans' secondary has made gradual improvements, but who better to find and expose a breakdown in coverage than Brady -- especially now that he has so many diverse playmakers to work with in Mike Evans, Rob Gronkowski, Brown and possibly Chris Godwin (if he is healthy)? -- Mike Triplett
Stat to know: Saints running back Alvin Kamara has six straight games with 100 scrimmage yards, the longest active streak in the NFL and the longest streak by a Saints player since Deuce McAllister's team-record nine-game streak in 2003. Kamara's 27 career games of 100 scrimmage yards are tied with Joe Horn for third in franchise history.
What to know for fantasy: In his past three matchups with the Saints, Evans has just five catches on his 119 routes run. See Week 9 rankings.
Betting nugget: All seven New Orleans games have gone over the total this season. Read more.
Triplett's pick: Buccaneers 27, Saints 23
Laine's pick: Buccaneers 29, Saints 26
FPI prediction: TB, 64.9% (by an average of 5.2 points)
Matchup must-reads: Scars of the NFL's QB guard: How Brees, Brady and others have worked through injuries ... Brown says he's grateful to be back in football ... Saints are 5-2 because Kamara is making NFL history ... What can the Buccaneers expect from receiver Brown?