Furman ran 60 times for 460 yards and finished with 647 yards of total offense. Wynn's 217 yards rushing ranked ninth in program history. Grainger was 6 of 9 for 183 yards and no interceptions.
Furman (4-2, 3-0 Southern Conference) scored on its first nine possessions -- seven straight touchdowns followed by a field goal and a touchdown that capped the scoring early in the fourth quarter.
Samford (3-3, 2-1) scored on the opening possession of the game. But Wynn went 75 yards on Furman's first play from scrimmage, tying it at 7-all and sparking a 35-point run.
The Paladins led 28-7 at the end of the first quarter and 42-14 at halftime.
Jay Stanton ran eight times for 77 yards for the Bulldogs.
Scott's 3 TD passes helps Nicholls beat Northwestern State
— Lindsey Scott Jr. threw two of his three touchdown passes to Dai'Jean Dixon, Julien Gums had 36 carries for 156 yards and a score, and Nicholls beat Northwestern State 31-24 on Saturday night.
Travis Etienne bringing his big-play ability to the NFL
Check out the highlights that make Clemson's Travis Etienne a coveted RB prospect ahead of the 2021 NFL draft.
Rodrigues throws 3 TDs, leads UC Davis over Idaho 27-17
— Hunter Rodrigues threw three touchdown passes and UC Davis beat Idaho 27-17 on Saturday.
Furman rallies from 17 down, beats Samford 44-37 in OT
— Ryan Miller scored the tying touchdown with 2:53 left in the fourth quarter, and Furman rallied from a 17-point deficit to beat Samford 44-37 in overtime on Saturday.
Deion Sanders celebrates after Jackson State ices win with fumble recovery
Jackson State recovers a fumble right at their own goal line to win and head coach Deion Sanders is pumped up.
Deion Sanders runs with his receiver Baldwin on 64-yard touchdown
Jackson State's Daylen Baldwin breaks free for the 64-yard touchdown and his head coach Deion Sanders runs with him down the sidelines.