The Hurricanes announced the decision with a one-sentence statement: "The University of Miami football program announced Friday that Dan Enos has been relieved of his duties as offensive coordinator/quarterbacks coach."
On Thursday, Miami athletic director Blake James gave head coach Manny Diaz a vote of confidence, but James said "changes are necessary" after the Hurricanes completed their second losing season in 12 years.
The Hurricanes went 6-7 this season and struggled offensively in their only year under Enos, averaging 25.7 points per game.
Miami's 14-0 loss on Thursday night was the first shutout in the Independence Bowl's 44-game history.
Miami is ranked 89th nationally in scoring offense, 99th in total offense, 122nd in rushing offense and 122nd in red zone offense. It used three quarterbacks in the 14-0 bowl loss, managing only 227 yards of offense.
The Hurricanes finished the year on a three-game losing streak and are ranked 129th in third-down conversion percentage (27.2%) -- ahead of only winless Akron (26.4%).
"Our execution on offense and our inability to sustain drives on offense gave us no chance to win this football game," Diaz said after the Independence Bowl.
The bowl loss also marked the first time that a Group of 5 program has shut out a Power 5 school in a bowl game since the beginning of the BCS/College Football Playoff era in 1998, according to Stats Inc.
Enos, 51, served as an offensive assistant at Alabama last season. He was the head coach at Central Michigan from 2010 to 2014 before spending the next three seasons as Arkansas' offensive coordinator.
"The whole season has a what-could-have-been aspect to it," Diaz said. "Whether that's the close losses early in the year, or the way things just kind of fell apart especially offensively in the last three games. But everything that happened happened exactly for a reason, and it has brought us to this point, and when you come to a point like this there is a lesson that has to be learned."
The Associated Press contributed to this report.