Alex Dowsett of Team Israel Start-up Nation took a second career Giro d'Italia win when he soloed to victory in the eighth stage, a 200-km trek from Giovinazzo to Vieste on Saturday.
The six-time individual time trial British champion attacked from a small group of breakaway riders some 17km from the finish and maintained his advantage to beat Italian Salvatore Puccio and another Briton Matthew Holmes.
Dowsett's first grand tour win was at the Giro d'Italia in 2013.
Portugal's Joao Almeida retained the overall leader's Maglia Rosa after a quiet day in the main bunch.
The overall contenders are set to be the main focus on Sunday when the ninth stage takes the peloton over 208km from San Salvo to Roccaraso in the Abruzzo mountains.
Briton Simon Yates of the Mitchelton-Scott team was withdrawn from the race on Saturday after testing positive for the coronavirus.