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Genoa, Italy's oldest professional club, guaranteed Serie A survival on the final day of the season, while Lecce were relegated to Serie B.
Inter Milan put more pressure on stuttering Serie A leaders Juventus when two goals by Romelu Lukaku helped them to a 3-0 win over Genoa.
Genoa moved closer to safety when they beat neighbours Sampdoria 3-1 in the Lighthouse Derby on Wednesday while Brescia were relegated.
Torino captain Andrea Belotti scored for the seventh game in a row to complete a 3-0 win over relegation-threatened Genoa in Serie A.
Genoa boosted their hopes of Serie A survival with a 2-0 win over bottom-of-the-table SPAL on Sunday, their first win in six games.
A second-half goal from Hirving Lozano gave Napoli a 2-1 win at struggling Genoa in Serie A on Wednesday.
Juventus secured a 3-1 win at lowly Genoa on Tuesday to stay four points clear at the top of Serie A.
Juventus coach Maurizio Sarri still believes that playing at home continues to offer an advantage despite matches being played without fans.
Genoa hit back with two penalties to force a 2-2 draw at Brescia as the struggling sides defied sweltering temperatures in an entertaining match.
Parma striker Andreas Cornelius scored a hat trick against Genoa for the second time this season.