Bayer Leverkusen slumped to a 2-1 home loss to Freiburg on Sunday to drift further away from a top-four finish and cap a dismal week.
Schalke's problems continued as they sacked their first-team staff to become the first Bundesliga club with five different coaches in a season.
RB Leipzig's Alexander Sorloth headed in a stoppage-time winner as they battled back from two goals down to beat visitors Borussia Monchengladbach.
Borussia Dortmund scored three second-half goals to ease past struggling Arminia Bielefeld 3-0 on Saturday.
Bundesliga top scorer Robert Lewandowski and Serge Gnabry both struck twice as Bayern Munich crushed Cologne 5-1 on Saturday.
Werder Bremen's United States forward Josh Sargent scored the winner as his struggling side rallied past Eintracht Frankfurt.
RB Leipzig defender Angelino said Pep Guardiola "killed" his confidence during their time together at Manchester City.
Bayern Munich teenager Jamal Musiala has decided to play for the Germany national team instead of England after a talk with head coach Joachim Loew.
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