AC Milan forward Ante Rebic scored the winning goal they beat Brescia 1-0, sparing the blushes of Zlatan Ibrahimovic.
The Derby della Capitale is always intense but with Lazio in the title race and Roma battling for fourth, Sunday's derby means even more than usual.
The Egyptian's finish against Manchester United may prove to be one of the defining images of Liverpool's side's utter conviction in their destiny.
Free-scoring Atalanta missed a chance to move back into the top four of Serie A when they suffered a shock 2-1 home defeat on Monday against SPAL.
Manchester United cannot bring back Alexis Sanchez to ease their injury crisis because there is no recall clause, sources have told ESPN.
Mario Balotelli was sent off seven minutes after coming on at the weekend after insulting a referee.
Cristiano Ronaldo struck twice to continue his sensational scoring run and help move Juventus four points clear at the top of Serie A.
AS Roma returned to winning ways and moved into fourth place in Serie A with a 3-1 win at troubled Genoa on Sunday.
Inter Milan were held to a 1-1 draw by relegation-battling Lecce in Serie A on Sunday, dropping points for the second weekend in a row.
Ante Rebic broke his AC Milan duck by scoring two second-half goals including a stoppage-time winner to give them a thrilling 3-2 win over Udinese.
Fiorentina moved above Napoli in Serie A and consigned coach Gennaro Gattuso to a fourth defeat in five games with a 2-0 win at Stadio San Paolo.