Manchester United pair Jesse Lingard and Anthony Martial were sent home from training on Friday just 15 minutes after arriving after being struck down with illness, sources have told ESPN.
Lingard and Martial arrived at Carrington on Friday morning but were ordered home just minutes later after being checked over by club medical staff.
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It is a further blow for manager Ole Gunnar Solskjaer ahead of United's FA Cup third round tie at Wolves on Saturday after losing influential midfielders Paul Pogba and Scott McTominay to injury.
"There are a couple of niggles, well not niggles, illnesses and colds, which is normal for this time," Solskjaer told a news conference on Friday.
"I'll have to see who wakes up tomorrow [Saturday] and feels OK. Today [Friday] we have got a training session as well."
Martial and Lingard are both now doubtful for the trip to Molineux -- where United were knocked out of the FA Cup last season -- while Pogba, McTominay, and Axel Tuanzebe have already been ruled out.
Solskjaer has said Sergio Romero will play in goal in place of David De Gea and Mason Greenwood is also set to start.