Vanarama National League side Macclesfield produced an FA Cup shock as they dumped out Sky Bet League One Walsall with a 1-0 victory.
There are 46 places between the clubs but John McCombe's header enhanced the Silkmen's giant-killing reputation, having beaten Swindon and Cardiff in the cup in recent seasons.
Walsall could have led after nine minutes as Joe Edwards ran half the length of the pitch but was denied a superb solo goal by Craig Ross's low save.
Macclesfield's winner came in the 23rd minute when Walsall goalkeeper Neil Etheridge rushed from his box to foul Paul Lewis out wide and McCombe glanced home the resulting free-kick from Danny Whitaker.
Etheridge redeemed himself with a superb fingertip save to claw Danny Rowe's 20-yard strike away from the bottom corner.
Walsall ended the half strongly but could not find an equaliser as Erhun Oztumer's fierce strike was kept out by the strong palm of Ross.
Etheridge's poor clearance almost gifted Macclesfield a second goal in the first minute of the second half but Jack Sampson struck the post from a tight angle.
The miss never looked like proving costly, though, as Macclesfield defended superbly and almost grabbed a late second as Whitaker curled inches wide.
English FA Cup News
Abraham 'the most impressive' out of Chelsea's fringe players
Stewart Robson says Tammy Abraham was the pick of the bunch in Chelsea's 1-0 FA Cup win vs. Barnsley.
Pulisic's performance in Chelsea's narrow win at Barnsley will do little to convince Tuchel he deserves a greater role
Making his first start under Thomas Tuchel at Barnsley, Christian Pulisic didn't do much to suggest he should be in a starring role for Chelsea.
Tuchel not satisfied with FA Cup win: 'We clearly can play better'
Chelsea manager Thomas Tuchel said his team didn't show enough courage in their narrow 1-0 win over Barnsley in the FA Cup on Thursday.
Abraham seals Chelsea's FA Cup quarterfinals spot in win over Barnsley
Tammy Abraham's second-half goal secured secured Chelsea their spot in the FA Cup quarterfinals with a win at Championship side Barnsley.
Tammy Abraham appears to be offside in Chelsea goal
FA Cup: Tammy Abraham (65') Barnsley 0-1 Chelsea
Southampton see off Wolves to reach FA Cup quarterfinals
Second-half goals from Danny Ings and Stuart Armstrong earned Southampton a 2-0 win at Wolverhampton Wanderers on Thursday.