Uruguay coach Oscar Tabarez has relied heavily on experience in his 23-man squad for the Copa America, including Barcelona star Luis Suarez, who is recovering from an injury.
However, Suarez is still a doubt for the tournament as he is recovering from surgery on his right knee.
The only player from Uruguay's domestic league to be included was Penarol's 24-year-old midfielder Giovanni Gonzalez, while the Seattle Sounders' Nicolas Lodeiro is the only player to come from Major League Soccer.
Uruguay has won the Copa America 15 times. Argentina has 14 trophies of the tournament, while host Brazil only has eight.
Uruguay'a first match will be on June 16 against Ecuador. Chile and Japan are also in Group C.
Midfielders: Matias Vecino (Inter Milan), Nahitan Nandez (Boca Juniors), Federico Valverde (Real Madrid), Giorgian de Arrascaeta (Flamengo), Rodrigo Bentancur (Juventus), Nicolas Lodeiro (Seattle Sounders), Lucas Torreira (Arsenal), Diego Laxalt (AC Milan), Gaston Pereiro (PSV Eindhoven), Giovanni Gonzalez (Penarol).