The school announced the event Friday, with doubleheaders taking place Nov. 25 and Nov. 27 at Bramlage Coliseum.
The Wildcats will face Drake on the first day, while Colorado will meet South Dakota State. On the second day, Kansas State faces Colorado and Drake plays South Dakota State.
The Kansas State-Colorado matchup reunites programs that were in the same conference from 1948 to 2011, most recently in the Big 12 before the Buffaloes moved to the Pac-12.
The NCAA has delayed the start of the season to Nov. 25 due to the coronavirus pandemic. The Little Apple Classic replaces the canceled Cayman Islands Classic on the Wildcats' schedule.