The Reds got one back when Freddy Galvis and Aristides Aquino opened the bottom half with consecutive doubles. Aquino advanced to third on Curt Casali's fly ball to center, but Joe Jiménez got Joey Votto to bounce into a game-ending double play for his second save in two days.
José Cisneros (1-0) pitched the eighth for the win.
Cincinnati played without second baseman Mike Moustakas and center fielder Nick Senzel after each player was scratched. Moustakas was placed on the injured list because he wasn't feeling well, according to manager David Bell. No immediate reason was given for Senzel's absence.
The moves came a day after Reds infielder Matt Davidson went on the injured list because he tested positive for COVID-19.
Cincinnati wasted a terrific pitching performance for the second straight game. Trevor Bauer matched a career high by striking out 13 in 6 1/3 innings.
Luis Castillo struck out 11 and handed a 3-1 lead over to Cincinnati's bullpen on Saturday. But Robert Stephenson, Lorenzen and Raisel Iglesias allowed home runs in what became a 6-4 victory for the Tigers.
Cron also went deep in Detroit's 7-1 loss on opening day, making a nice first impression after he signed with the Tigers in free agency.
The Tigers jumped in front in the series finale on Niko Goodrum's third-inning homer. But Votto responded with a tying RBI single in the fifth.
Spencer Turnbull pitched five effective innings for Detroit in his first start since he went 3-17 with a 4.61 ERA last season. He struck out eight and issued four walks.
Reds: C Tyler Stephenson was recalled to take Moustakas' roster spot. ... 2B Josh VanMeter stayed in the game after he was hit on the left wrist with a pitch leading off the sixth.
Tigers: RHP Michael Fulmer makes his first appearance since Sept. 25, 2018, in a start against Kansas City on Monday. The 2016 AL Rookie of the Year underwent Tommy John surgery in March 2019.
Reds: LHP Wade Miley (14-6 with Astros in 2019) makes his Cincinnati debut in the opener of a four-game series against the Cubs on Monday.
New York Yankees' Gary Sanchez exits game with injured hand, X-rays negative
New York Yankees catcher Gary Sanchez's throwing hand was unprotected when Tampa Bay's Randy Arozarena tipped a pitch that appeared to hit Sanchez in the knuckles in the fourth inning.
Former New York Yankees pitcher Masahiro Tanaka allows two homers, loses in return to Japanese baseball
Masahiro Tanaka allowed Sho Nakata's two-run homer in the first inning of the pitcher's return to Japanese baseball, a 4-1 loss for the Tohoku Rakuten Golden Eagles to the Hokkaido Nippon Ham Fighters at the Tokyo Dome on Saturday.
Atlanta Braves call up Sean Kazmar Jr., who last played in majors in 2008
The Braves placed Sean Kazmar Jr. on the active roster Saturday. The 36-year-old infielder appeared as a pinch hitter in the fifth inning for his first major league action since September 2008.
Tampa Bay Rays' Kevin Kiermaier tests quad, activated from 10-day IL
The Tampa Bay Rays activated Gold Glove center fielder Kevin Kiermaier from the 10-day injured list prior to a game Saturday at Yankee Stadium.
Kansas City Royals trade OF Mike Heath to Arizona Diamondbacks for minor league pitcher
Nick Heath, who had been designated for assignment earlier in the week, has been on the fringe of making the Royals' major league club the past several years.
Seager's homer in 12th sends Dodgers to 11-6 win over Padres
— Corey Seager hit a tiebreaking, two-run homer on Tim Hill's first pitch of the 12th inning and the Los Angeles Dodgers beat the San Diego Padres 11-6 Friday night in a tense, entertaining first matchup this season between NL West rivals who have...