Mills (5-4) overcame a rocky start to pitch six innings for his first win since July 7. Wisdom finished with three hits.
“It’s nice when you have a guy that throws that hard and the ball moves that much. Picks up a big save for us,” Cubs manager David Ross said. “That was a nice outing from Manny.”
Raimel Tapia had two doubles and nearly made a run-saving catch for Colorado.
Rockies starter Jon Gray (7-7) walked one batter over six innings and it came back to hurt him. After getting the first two outs of the fifth he gave up consecutive singles to Rafael Ortega and Willson Contreras and then walked Ian Happ, a .177 hitter, to load the bases.
Wisdom hit a ball to the wall in left field that Tapia had in his glove, but it fell out when he hit the fence, allowing all three runners to score.
“I feel bad. I should have had it,” Tapia said through a translator.
Wisdom made a bid for his 17th homer but fell just short.
“I didn’t square it up flush like a no-doubter, but I knew we were in Colorado and some weird things can happen,” he said.
Gray has pitched well since returning from the 10-day injured list on June 25. He was 3-0 with a 2.61 ERA in his previous seven starts and came within a pitch of tossing six shutout innings.
“I don’t know if I got a little lazy with what I was throwing, but if we throw a fastball there we probably get him out,” Gray said about Wisdom’s double. “I wasn’t attacking the zone, I felt like. A lot of hits, a lot of traffic.”
Colorado got both its runs in the first, on back-to-back doubles by Tapia and Brendan Rodgers to open the inning followed by a wild pitch and a groundout.
“Millsy’s been really consistent,” Ross said. “I thought he was really impressive in this ballpark. The hits he gave up in the first, the two runs, and then keep it right there was really impressive in this environment that can be really tough on pitchers.”
Rodgers finished with three hits.
Rockies: Manager Bud Black said LHP Kyle Freeland was feeling fine a day after getting hit on the left foot with a line drive. Black said it was too early to know if Freeland would make his next scheduled start.
All but the top of the first inning was played with three umpires after plate ump Kerwin Danley left the game due to back spasms. Danley was noticeably limping as he walked slowly to the exit behind home plate with the help of Rockies trainers to receive medical treatment
Roberto Ortiz moved from second base behind home plate for the rest of the game.
Danley will not work Thursday afternoon’s game, the Rockies announced.
Left fielder Johneshwy Fargas made his Cubs debut and showed why he was claimed off waivers from the New York Mets. With the Rockies leading 2-0, Ryan McMahon led off the fourth with a double and tried to tag up when Elías Díaz flied out to left. Fargas threw a one-hopper to Wisdom, who tagged out McMahon.
Colorado activated reliever Robert Stephenson (upper back tightness) from the 10-day IL and optioned right-hander Antonio Santos to Triple-A Albuquerque.
Chicago RHP Jake Arrieta (5-10, 6.20 ERA) will make his second start since returning from the 10-day injured list. Colorado is expected to activate RHP Antonio Senzatela (2-8, 4.58) after a stint on the IL due to COVID-19 protocols.
Perez breaks Bench's record with 46th HR, KC tops Indians
— Salvador Perez hit his 46th home run, breaking Johnny Bench’s record for homers by a catcher in a season, and the Kansas City Royals beat the Cleveland Indians 7-2 Monday in the first game of a doubleheader.
Right fielder Adam Engel 'feels good,' will be activated by Chicago White Sox with playoffs on horizon
At long last, the White Sox will have their starting outfield back in full, as right fielder Adam Engel is set to be activated from the injured list on Tuesday, according to Chicago manager Tony La Russa.
Salvador Perez ties MLB lead with his 46th HR of the season
Royals catcher Salvador Perez ties Vladimir Guerrero Jr. atop MLB's home run leaderboard with his 46th long ball of the year.
Anthony Gose, 31, former outfielder converted to reliever, promoted by Cleveland Indians
Formerly an outfielder in the big leagues, Anthony Gose, who played for Team USA in the Tokyo Olympics, was called up from the minors by the Cleveland Indians on Monday, this time as a hard-throwing lefty reliever.
Struggling New York Yankees activate pitcher Luis Severino, send former All-Star to bullpen
Former All-Star pitcher Luis Severino was activated by the New York Yankees before Monday's series opener against the Texas Rangers and is in position to make his first major league appearance in nearly two years.
Top six adds for fantasy baseball playoff matchups
If you're in your fantasy finals matchup, or needing just a little push in roto leagues, Tristan offers six players with something to prove this week.