The Dodgers replaced him on the 30-man roster with minor league reliever Josh Sborz.
Wood's injury, listed as shoulder inflammation, comes one week after Clayton Kershaw's back stiffened up, an ailment that ultimately kept him out of his Opening Day start. Before that, Jimmy Nelson underwent back surgery and was ruled out for the year, and David Price chose not to participate in the 2020 season because of health concerns.
Dennis Santana and Tony Gonsolin stand out as the lead internal options to replace Wood in the rotation, which is now down to Walker Buehler, Julio Urias, Ross Stripling and Dustin May. Kershaw, who threw a bullpen session in Houston on Wednesday and was scheduled to throw another one in Arizona on Thursday, could return this weekend but is not expected to take the ball on Friday.
Wood, who rejoined the Dodgers with a one-year, $4 million contract this offseason, gave up three runs and allowed six baserunners in three innings against the San Francisco Giants on Saturday. The 29-year-old left-hander was limited to seven starts with the Cincinnati Reds last season because of back issues.
Dodgers manager Dave Roberts said Wood had been experiencing some semblance of shoulder inflammation for a couple of weeks and continued to do so after his 2020 debut. The Dodgers also realized that Wood had been dropping his arm slot, an indication that Wood was compensating for pain. Roberts didn't provide a timetable, but said he should return "soon."
"This is not anything that's serious," Roberts said. "It's just something that popped up and we feel good that he'll be back to throwing the baseball the way he was and be healthy."