Cyborg beat Smith in 2016 in what was Cyborg's UFC debut. Cyborg (23-2, 1 NC) is one of the best female fighters of all time. The Brazilian slugger is coming off a second-round submission win over Arlene Blencowe last October. That was Cyborg's first title defense.
Cyborg, 35, stopped Julia Budd by fourth-round TKO in January 2020 to win the title. That victory made Cyborg the first fighter to win titles in four major promotions: UFC, Bellator, Strikeforce and Invicta.
Since 2005, Cyborg has been defeated only by UFC double champion Amanda Nunes. Cyborg left the UFC when her contract expired in 2019 after a rocky tenure.
Smith (12-8-1) has won four of her past five fights. The California native is coming off a unanimous decision over Amanda Bell last September.
Smith, 38, was finished by Cyborg in 1:21 at UFC 198 on May 14, 2016, but disputed that, saying it was an early stoppage.
She is best known for her attempts to organize MMA fighters, who don't have a union or association.