Okafor was injured while sacking Denver quarterback Drew Lock. He immediately left the game and didn't return.
Okafor has five sacks this season, which ranks fourth on the Chiefs. Third on that list is defensive end Emmanuel Ogbah (5.5), but he is also done for the season after tearing a pectoral muscle last month.
Without Okafor, the Chiefs are down to three true defensive ends: Frank Clark, Tanoh Kpassagnon and Demone Harris. Clark is second on the Chiefs with six sacks; Kpassagnon is fifth with four. Harris recently joined the Chiefs off the Baltimore Ravens' practice squad.
In his first season with the Chiefs, Okafor has missed four games because of injuries. He didn't play in Week 5 against the Indianapolis Colts because of a hip injury. He then missed three games in November because of a high ankle sprain.