Pryor was in close contact with someone outside of the building who had the virus, a source told ESPN. He hasn't tested positive, and the team will go through the necessary protocol.
Right tackle Lane Johnson, meanwhile, also has been ruled out due to an ongoing ankle issue. Rookie Jack Driscoll will get the nod in his place, leaving center Jason Kelce as the only original member of the Eagles' starting offensive line playing this week.
The Eagles also will be without receivers DeSean Jackson (hamstring), who had what Pederson said was a good practice Thursday, and Alshon Jeffery, who is still reacclimating to the practice field following a long recovery from a Lisfranc surgery.
Philadelphia opted not to place Jeffery on the physically unable to perform list at the start of the season, hoping he would return within the first six weeks of the season.
Cornerback Darius Slay has cleared concussion protocol and will play Sunday if he remains symptom-free. He is listed as questionable.
Pederson is not permitted to say whether Pryor has tested positive for the coronavirus.
"We have to take every precaution, whether a guy has an upset stomach or a headache or whatever it could be -- it doesn't even have to be COVID-related. We have to take everything seriously and we've got to protect the entire team and the organization," Pederson said.
The NFL's chief medical officer, Dr. Allen Sills, on Thursday said that the league is isolating players with COVID-19 symptoms, even if tests are negative, until they can rule out COVID-19, which could lead to missed games.