Cruz: Seahawks have all the power with Brees out (0:50)

Stephen A.: If Saints win the Super Bowl, Brees retires (1:24)

AP Photo/Rick Scuteri

1dNFL Nation

Biggest Week 3 injury questions for all 32 NFL teams: Latest on Johnson, Singletary, Williams and more

The three running backs are among the players in question for Week 3. Get the latest updates on their prognoses from our NFL Nation reporters.

Bridgewater: 'Only one Drew Brees' (1:08)

Sean M. Haffey/Getty Images

2dMike Triplett

Brees has surgery on thumb; Saints to use 2 QBs

Sean Payton declined to name a starter for the Saints' first game without Drew Brees on Sunday at Seattle, saying, "We'll approach this game with two quarterbacks" in veteran Teddy Bridgewater and dual-threat athlete Taysom Hill.

2d

Bridge Over Troubled Water

Mina and ESPN Rams reporter Lindsey Thiry discuss the injuries to Drew Brees and Ben Roethlisberger, the Steelers trading for Minkah Fitzpatrick, Jalen Ramsey demanding a trade, the best three teams in the NFC, Mina's fascination with a third string quarterback, and "normies."

AP Photo/Marcio Jose Sanchez

3dMike Triplett

Brees to have thumb surgery on Wednesday

After having his injured passing hand examined by two specialists, Saints QB Drew Brees has decided to have surgery Wednesday in Los Angeles.

AP Photo/Bill Feig

3dBill Barnwell

Barnwell: All the fallout from the Big Ben and Brees injuries

The Steelers quarterback is out for the season, while the Saints QB could miss six games. Here's what's next for both franchises.

ESPN.com Illustration

3dNFL Nation

Week 3 NFL Power Rankings - 1-32 poll, plus the most pleasant surprise for each team

While we track teams moving up (Cowboys, Ravens) and down (Saints, Steelers) in our rankings, we also identify each team's early-season surprise.

Stephen Lew/Icon Sportswire via Getty Images

3dMike Triplett

Saints starting MLB Anzalone placed on IR

Starting middle linebacker Alex Anzalone was placed on injured reserve with an unspecified injury.

Clark: Super Bowl hopes could go out the window with Brees' surgery (1:58)

Stephen A.: 'The Saints are done without Drew Brees, period' (1:00)

Sean M. Haffey/Getty Images

4d

Sources: Brees surgery likely, could miss 6 weeks

Saints QB Drew Brees is expected to undergo thumb surgery that could sideline him about six weeks, league sources told ESPN's Adam Schefter.

Photo by Brad Penner/USA TODAY Sports

4dDan Graziano

Let's overreact to Week 2 in the NFL: Bench Eli for the rookie now

The Giants are going nowhere, so it's time to start first-round pick Daniel Jones ... right?

4d

Brees injured, Rams beat Saints 27-9 in title game rematch

With Drew Brees watching from the sideline with an injured hand, the Los Angeles Rams didn't need a no-call to beat the New Orleans Saints again.

Sean M. Haffey/Getty Images

4dMike Triplett

Saints suffer another officiating error vs. Rams

Saints defensive end Cameron Jordan appeared to return a fumble 87 yards for a touchdown, but officials whistled the play dead.

Sean M. Haffey/Getty Images

5dMike Triplett

Brees 'concerned' about injury, to see specialist

Saints quarterback Drew Brees left Sunday's loss to the Rams in the first quarter after injuring his thumb.

Mark J. Rebilas-USA TODAY Sports

5dMike Triplett

Saints extend Payton for 5 years, through 2024

Sean Payton signed a five-year extension with the New Orleans Saints, meaning one of the NFL's longest-running partnerships will continue well into its second decade.

Kezirian: New Orleans is a different team outside of the dome (1:18)

Young: Rams-Saints involves major implications (0:18)

Ninkovich: Saints will be motivated in Rams' rematch (0:48)

Gerald Herbert/AP

8dLindsey Thiry

Rams' Talib: Botched PI call 'not an L.A. problem'

As they prepare to play the Saints in a rematch of last season's NFC Championship Game, the Rams are still fielding questions about the infamous pass interference no-call that helped send them to Super Bowl LIII.