Uncapped full-back Jonah Holmes will make his first Wales appearance on Saturday after Warren Gatland made 14 changes to his starting line-up for the visit of Tonga.
Ellis Jenkins captains the side for the second time and is joined in the starting XV by winger Liam Williams and fly-half Dan Biggar.
Lock Adam Beard is the only player to maintain his place from last weekend's win against Australia, as head coach Gatland seized the opportunity to rotate his squad ahead of the fixture against South Africa next week.
"Saturday is a fantastic opportunity for a number of players," Gatland said. "It's Jonah's first game which is exciting and Liam reaches his 50th cap which is a great achievement.
"We are looking forward to the challenge of Tonga. They had a great win last weekend against the French Barbarians and we know it is going to be a tough, physical challenge.
"We have spoken about creating depth and for us that is all about creating a squad that is full of first-teamers, everyone in the squad capable of starting. The boys this weekend have to put their hand up for the final match and put pressure on the players who started last weekend."
Wales team to play Tonga
15. Jonah Holmes 14. Liam Williams 13. Tyler Morgan 12. Owen Watkin 11. Steff Evans 10. Dan Biggar 9. Tomos Williams; 1. Wyn Jones 2. Elliot Dee 3. Leon Brown 4. Jake Ball 5. Adam Beard 6. Aaron Wainwright 7. Ellis Jenkins (captain) 8. Seb Davies
Replacements: 16. Ryan Elias 17. Rob Evans 18. Tomas Francis 19. Cory Hill 20. Ross Moriarty 21. Aled Davies 22. Rhys Patchell 23. Josh Adams