Stefanos Tsitsipas cruised into the Open 13 Provence quarterfinals with a straight sets victory on Wednesday.
The No.2 seed overcame Sweden's Mikael Ymer 6-1, 6-3 to set up a clash against Vasek Pospisil in the last eight.
Tsitsipas won the competition last year and he is looking to secure back-to-back titles at a tour event for the first time in his career.
Pospisil needed 88 minutes to seal a 6-3, 6-4 win against No. 8 seed Hubert Hurkacz.
Kazakhstan's Alexander Bublik knocked out sixth seed Benoit Paire to progress into the quarterfinals after he recovered from a set behind to win 3-6, 6-4, 6-4.
Bublik will face either No.4 seed Denis Shapovalov or Marin Cilic in the next round.
Meanwhile in the round of 32, Canada's Felix Auger-Aliassime, France's Pierre-Hugues Herbert and Belarusian Egor Gerasimov all advanced into the next round.